Southampton make their third trip to Merseyside this season as they face Everton at Goodison Park on Tuesday in the Carabao Cup.
The Saints have already tasted defeats to Everton and Liverpool respectively in the league and will be hoping to get back to winning ways.
Southampton progressed to this stage of the Carabao Cup thanks to a narrow 1-0 win over Brighton, with a late Charlie Austin header proving to be decisive.
As for the Toffees, they eased through to this stage after seeing off Championship side Rotherham 3-1 at home.
After tasting defeat in their previous two encounters, a win is a must for this Southampton side as they look to breed some confidence ahead of some testing Premier League outings.
Everton will also be keen to find the right result after having a mixed start to the season, claiming just two wins.
Despite this, there are likely to be a number of changes for both with fringe players given a rare opportunity to impress and stake a claim for regular starting berths.
The winner of this tie has the incentive of a trip to Leicester City in the fourth round after the draw was made on Saturday evening.
In terms of team news, Shane Long is being monitored ahead of the game after missing the trip to Wolves due to a toe injury. Elsewhere, there are no other fresh concerns and Mark Hughes is likely to rotate his side.
As for the hosts, they have a number of players out of this one. James McCarthy, Andre Gomes, Yerry Mina, Seamus Coleman, Beni Baningime have all been ruled out of this tie.
Saints boss Hughes spoke prior to the game, admitting that he is planning to make changes in order to give players, who perhaps haven’t played as much as they should have, valuable minutes.
We’ll make changes. We made changes against Brighton and put out a really good performance and a number of those players made a claim and are pushing themselves more into my thinking.
I fully expect that a number of the players that will play on Tuesday will do the same, but that’s up to them. They need to show me they are able to help us.
They’re all good players and some of them have been disappointed. It’s been a bit unfair to them, they haven’t done anything wrong, but we’ve got a fully fit squad that I can’t pick everybody.
With both sides set to make a number of changes to their normal line-ups, it’s likely to be quite a drag encounter, but one which offers some opportunities for the out of favour players to perform in.
I feel that the match will be drawn 1-1 in 90 minutes, before Saints win it on penalties.