Michael Obafemi could miss up to two weeks with a knock according to Saints boss Ralph Hassenhuttl.
Obafemi has been out with a knock, and looks set to miss the clash with Derby County on Saturday.
Saints will take on the Rams in the FA Cup, and will look to go on a run in the competition.
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Having recently committed to the Republic of Ireland, Obafemi has broken his way into the Southampton side.
The Irish striker has one goal to his name so far, after netting against Huddersfield in a crucial win for Ralph Hassenhuttl.
The striker will miss the trip to Pride Park on Saturday, but could return in time for the Premier League matchup with Leicester City, but could be a doubt for the clash with the Foxes.
